Protein Labeling & Cross linking
Explora's custom protein labeling & crosslinking service provides personalized solutions designed to supply researchers with the widest choice of labels and cross linkers to meet their specific needs. Protein modification and crosslinking has emerged as a powerful tool for several different application field such as:

• Enzyme & Antibody modifications and conjugations (biotin, chromo- and fluorophores, PEGgylation)
• Oligo modification and labeling
• Nanoparticle functionalization (e.g gold-labeled, magnetic nanoparticles, silica particle)
• Surface immobilization (e.g. Microtitre wells, silica and gold slides)
• Development of 'small' molecule drug & enzyme conjugates to therapeutic antibodies
• Modification of key properties of therapeutic proteins to optimise PK/PD behaviour
• In-vivo protein trafficking and subcellular localization
• Conjugated biopharmaceuticals for targeted delivery of cytotoxic agents

Custom labeling fees start at €500 and include the conjugation of up to 1 mg of antibody or protein. On your behalf we carry out:

• Biomolecule-low molecular weight compounds labeling (e.g. protein-biotin, digoxigenin, FITC)
  
• Biomolecule-biomolecule conjugation (e.g. antibody-HRP or protein-oligo)
  
• Immobilization on solid supports (e.g. protein-magnetic nanoparticles, antibody-beads)
  

With a broad range of reagents:

• Fluorescent labels
• Chromophores
• Photoactivated labels
• Photolabile labels
• Cleavable labels

Furthermore, Explora can support you in analyzing critical variables affecting conjugate behaviour:

• Type of conjugation reaction: site-specific vs. random coupling
• Site of conjugation: to reduce steric hindrance, minimize negative impact on folding and activity
• Conjugate stoichiometry
• In vivo conjugate behaviour: cleavable vs. non-cleavable labeling
• Immunogenicity and In vitro stability of the linker group

Fill-in the form and our staff will contact you to discuss your labeling & cross-link needs.