Protein Labeling & Cross linking
Explora's custom protein labeling & crosslinking service provides personalized solutions designed to supply researchers with the widest choice of labels and cross linkers to meet their specific needs. Protein modification and crosslinking has emerged as a powerful tool for several different application field such as:

• Enzyme & Antibody modifications and conjugations (biotin, chromo- and fluorophores, PEGgylation)
• Oligo modification and labeling
• Nanoparticle functionalization (e.g gold-labeled, magnetic nanoparticles, silica particle)
• Surface immobilization (e.g. Microtitre wells, silica and gold slides)
• Development of 'small' molecule drug & enzyme conjugates to therapeutic antibodies
• Modification of key properties of therapeutic proteins to optimise PK/PD behaviour
• In-vivo protein trafficking and subcellular localization
• Conjugated biopharmaceuticals for targeted delivery of cytotoxic agents

Custom labeling fees start at €500 and include the conjugation of up to 1 mg of antibody or protein. On your behalf we carry out:

• Biomolecule-low molecular weight compounds labeling (e.g. protein-biotin, digoxigenin, FITC)
  
• Biomolecule-biomolecule conjugation (e.g. antibody-HRP or protein-oligo)
  
• Immobilization on solid supports (e.g. protein-magnetic nanoparticles, antibody-beads)
  

With a broad range of reagents:

• Fluorescent labels
• Chromophores
• Photoactivated labels
• Photolabile labels
• Cleavable labels

Furthermore, Explora can support you in analyzing critical variables affecting conjugate behaviour:

• Type of conjugation reaction: site-specific vs. random coupling
• Site of conjugation: to reduce steric hindrance, minimize negative impact on folding and activity
• Conjugate stoichiometry
• In vivo conjugate behaviour: cleavable vs. non-cleavable labeling
• Immunogenicity and In vitro stability of the linker group

Fill in the following form to ask for a quote.

*mandatory fields
_______________________________	_______________________________________	__________________________________
	STEP1. Your Target Data
Choose your target	Protein (up to 200KDa) AntibodyPeptide
Target approximate MW
	STEP2. Label & Crosslinker data
Label type	Protein/antibody (e.g. HRP/AP/Ab) Low MW compound (e.g biotin/Alexa/DyLight) DNA/RNA oligo (e.g primers/probes) Polymer (e.g. PEG) Surface (e.g. Agarose/Magnetic/xMap/AlphaLise beads/sepharose)
Quantity of target to be conjugated	XS: up to 0.1mg S: 0.1 - 1.0mg M: 1.0 - 5.0mg L: 5.0 - 10 mg XL: > 10mg
Do you want us to test the activity of your target after conjugation?	Yes No
	STEP3. Your details
Full Name *
Your Institution *		Please provide us institution name, Country, Streeet, ZIP Code
Your Email
Your Phone		e.g 001-901-987654321
Enter code (dark letters)

Please refeer to our list of in-house available low molecular weight labels. If you don't find the label your are looking for, provide us with the Manufacturer name and catalogue number and we will purchase it on your behalf.