Protein Labeling & Cross linking starting from 500 €
Explora’s custom protein labeling & crosslinking service provides personalized solutions designed to supply researchers with the widest choice of labels and cross linkers to meet their specific needs. Protein modification and crosslinking has emerged as a powerful tool for several different application field such as:
- Enzyme & Antibody modifications and conjugations (biotin, chromo- and fluorophores, PEGgylation)
- Oligo modification and labeling
- Nanoparticle functionalization (e.g gold-labeled, magnetic nanoparticles, silica particle)
- Surface immobilization (e.g. Microtitre wells, silica and gold slides)
- Development of ‘small’ molecule drug & enzyme conjugates to therapeutic antibodies
- Modification of key properties of therapeutic proteins to optimise PK/PD behaviour
- In-vivo protein trafficking and subcellular localization
- Conjugated biopharmaceuticals for targeted delivery of cytotoxic agents
Custom labeling fees start at €500 and include the conjugation of up to 1 mg of antibody or protein. On your behalf we carry out:
- Biomolecule-low molecular weight compounds labeling (e.g. protein-biotin, digoxigenin, FITC) see here a complete list of in house LMW compounds
- Biomolecule-biomolecule conjugation (e.g. antibody-HRP or protein-oligo)
- Immobilization on solid supports (e.g. protein-magnetic nanoparticles, antibody-beads)
With a broad range of reagents:
- Fluorescent labels
- Chromophores
- Photoactivated labels
- Photolabile labels
- Cleavable labels
Furthermore, Explora can support you in analyzing critical variables affecting conjugate behaviour:
- Type of conjugation reaction: site-specific vs. random coupling
- Site of conjugation: to reduce steric hindrance, minimize negative impact on folding and activity
- Conjugate stoichiometry
- In vivo conjugate behaviour: cleavable vs. non-cleavable labeling
- Immunogenicity and In vitro stability of the linker group