PROTEIN LABELING

Protein Labeling & Cross linking starting from 500 €

Explora’s custom protein labeling & crosslinking service provides personalized solutions designed to supply researchers with the widest choice of labels and cross linkers to meet their specific needs. Protein modification and crosslinking has emerged as a powerful tool for several different application field such as:

  • Enzyme & Antibody modifications and conjugations (biotin, chromo- and fluorophores, PEGgylation)
  • Oligo modification and labeling
  • Nanoparticle functionalization (e.g gold-labeled, magnetic nanoparticles, silica particle)
  • Surface immobilization (e.g. Microtitre wells, silica and gold slides)
  • Development of ‘small’ molecule drug & enzyme conjugates to therapeutic antibodies
  • Modification of key properties of therapeutic proteins to optimise PK/PD behaviour
  • In-vivo protein trafficking and subcellular localization
  • Conjugated biopharmaceuticals for targeted delivery of cytotoxic agents

Custom labeling fees start at €500 and include the conjugation of up to 1 mg of antibody or protein. On your behalf we carry out:

  • Biomolecule-low molecular weight compounds labeling (e.g. protein-biotin, digoxigenin, FITC) see here a complete list of in house LMW compounds
  • Biomolecule-biomolecule conjugation (e.g. antibody-HRP or protein-oligo)
  • Immobilization on solid supports (e.g. protein-magnetic nanoparticles, antibody-beads)

With a broad range of reagents:

  • Fluorescent labels
  • Chromophores
  • Photoactivated labels
  • Photolabile labels
  • Cleavable labels

Furthermore, Explora can support you in analyzing critical variables affecting conjugate behaviour:

  • Type of conjugation reaction: site-specific vs. random coupling
  • Site of conjugation: to reduce steric hindrance, minimize negative impact on folding and activity
  • Conjugate stoichiometry
  • In vivo conjugate behaviour: cleavable vs. non-cleavable labeling
  • Immunogenicity and In vitro stability of the linker group

QUOTE REQUEST FORM

Choose you Sample type
Choose you Label type
Choose type of chemistry
Type of spacer
Spacer Cleavability
Scale
Purity
Do you want us to test the activity of your sample after conjugation?
YesNo

Your name*
Your email*

If you are looking for a reliabile custom protein expression service you may want to have a look to our all-included protein expression service.